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Hormones and the Brain: Bridging the Mind-Body Connection

Hormones and the Brain: Bridging the Mind-Body Connection

Naturopathic medicine has come a long wayin the last three decades. It is now referred to as a complementary, not alternative, medicine, as naturopathic doctors will work with any allopathic treatment patients are receiving with respect to how both types of medicine provide the best health care possible.

Naturopathic Hormonal Health
Naturopathic doctors take a comprehensive approach to hormonal health, addressing the root causes of imbalance while prioritizing individualized care. To optimize brain function during hormonal transitions, naturopaths use a variety of strategies. We use diagnostics such as salivary, urine, or blood testing, which helps identify imbalances in estrogen, progesterone, testosterone, cortisol, and other hormones.

Hormones play a significant role in brain function, emotional health, and well-being, influencing the production of neurotransmitters like serotonin, dopamine, and norepinephrine, which play a major role in mood regulation. These biochemical messengers also affect memory, focus, and personality. This interplay between hormones and neurotransmitters is pronounced during certain life stages.

We all experience hormonal changes as we age. Our bodies undergo a number of changes, some affecting both genders similarly. Cortisol is one hormone that can increase and lead to stress-related health issues like anxiety, weight gain, and insomnia. The opposite can also happen, called adrenal fatigue. This condition occurs when the adrenal glands do not produce enough hormones, resulting in fatigue, weakness, mood change, sensitivity to stress, joint pain, weight loss, and hair loss.

The Complex Relationship Between Hormones and Neurotransmitters
Pregnenolone is a steroid hormone produced mainly in the adrenal glands, brain, and gonads that serves as a precursor to other hormones such as progesterone, cortisol, estrogen, testosterone, and DHEA sulfate. Though the research on pregnenolone’s direct effects on the brain is still evolving, it does have various impacts on brain function and cognitive health. Some studies suggest that pregnenolone could enhance memory and improve learning abilities, especially in age-related cognitive decline.

Pregnenolone has shown potential neuroprotection, helping protect brain cells from damage. This is crucial for certain conditions, such as Alzheimer’s and other neurodegenerative diseases. Pregnenolone could also influence depression and other mood disorders, such anxiety, regulating neurotransmitters such as GABA and serotonin, which help regulate mood.

Supplementing with pregnenolone has been suggested to help these age-related declines. Pregnenolone supports the brain’s ability to form new memories and retain information. It is a precursor to estrogen, progesterone, and testosterone, and it could influence the brain by maintaining a balance of these hormones.

Estrogen and testosterone are linked to cognitive performance and impact mood; progesterone influences GABA receptors to help relax and reduce stress. Pregnenolone is involved in cortisol regulation, influencing how the body and brain respond to energy demands during times of stress. It is a promising compound for brain health with potential applications in memory enhancement, mood regulation, stress support, and even neuroprotection in aging and neurodegenerative diseases.

Managing Hormone Changes
There are several ways to manage these hormonal changes, both natural and with medical intervention. Hormonal changes are a natural part of aging for both men and women, and understanding how they affect the body can help mitigate some of the symptoms and support long-term health. Following are some basic lifestyle guides.

  • Dietary guidance: A diet rich in antioxidants, omega-3 fatty acids, and phytoestrogens to support hormonal balance and brain health. Foods such as wild salmon, flaxseeds, leafy greens, and berries are particularly beneficial.
  • Exercise: NDs emphasize regular movement to reduce cortisol, enhance dopamine and serotonin, and improve overall mood stability.
  • Stress management: Practices such as mindful meditation, yoga, and deep breathing help lower cortisol and promote mental clarity.

Botanicals for Hormonal Support

  • Vitex (chaste tree berry): Balances estrogen and progesterone levels, easing symptoms of PMS and perimenopause.
  • Ashwagandha: Reduces cortisol and supports dopamine production, beneficial for anxiety and mood swings.
  • Maca root: Enhances energy and mood by supporting adrenal and hormonal balance.
  • Black cohosh: Helps mitigate mood swings and hot flashes during menopause.

Targeted Supplementation

  • Omega-3 fatty acids: Essential for reducing inflammation and supporting cognitive function.
  • Magnesium: Supports GABA activity, reducing anxiety and promoting relaxation.
  • B vitamins: Essential for neurotransmitter production, particularly B6, B9 (folate), and B12.
  • Vitamin D: Low levels are linked to mood disorders, making supplementation vital for brain health.

Hormones play a crucial role in brain health and emotional well-being. From influencing neurotransmitter activity to dictating emotional patterns through life’s stages, the mind–body connection is ever present. While hormonal shifts can create challenges, they also offer an opportunity for healing and growth when approached holistically.

Naturopathic doctors specialize in supporting individuals through these transitions, combining advanced testing, personalized treatment plans, lifestyle guidance, and natural therapies to optimize brain function and emotional resilience. Whether navigating the seven-year cycles of hormonal change or addressing specific imbalances, a comprehensive approach can empower individuals to thrive mentally and physically.

Dr. Keli Samuelson has been in practice since 1992, specializing in women’s health, hormonal disorders, clinical nutrition, digestive health, and family healthcare. Located at 210 South Main Street, Suite 200 in Middletown. Call 860.347.8600 to find out more.

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